Giometto B. Paraneoplastic Neurologic Disorders 2024
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Textbook in PDF format Paraneoplastic Neurological Disorders, Volume 200 covers new, recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. Besides investigating the pathogenetic mechanisms of these disorders, this book also explores what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy are teaching us in terms of immunopathogenesis. Following sections present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ, and muscle. Finally, the book investigates the role of antibody markers that differentiate by cytoplasmic, nuclear, and neuronal cell surface reactivities. Side effects of the new immuno-oncological drugs increasingly used in cancer therapy are also covered. Profiles paraneoplastic diseases by tumor typeIdentifies the pathogenetic mechanisms of PNS and provides epidemiological analysisPresents individual syndromes of the CNS, PNS, NMJ, and muscleInvestigates the role of antibody markersDifferentiates cytoplasmic, nuclear, and neuronal cell surface reactivitiesDiscusses immune-oncological drugs causing diseases that are indistinguishable from PNSReviews therapeutic strategies and clinical approach to PNS patients Introduction and Overview Introduction and overview of immunopathological mechanisms and future directions Changing landscape in the field of paraneoplastic neurology: Personal Perspectives over a 35-year career Pathogenesis and immunopathology of paraneoplastic disorders Paraneoplastic neurological syndromes Epidemiology of paraneoplastic neurologic syndromes Clinical approach to diagnosis of paraneoplastic neurological syndromes Overview of treatment strategies in paraneoplastic neurological syndromes Methods to Detect Paraneoplastic Antibodies Paraneoplastic encephalitis Autoimmune and paraneoplastic seizures Paraneoplastic Cerebellar and Brainstem Disorders Paraneoplastic/autoimmune myelopathies Paraneoplastic vision loss Paraneoplastic movement disorders Movement disorders associated with pediatric encephalitis Paraneoplastic neuropathies and peripheral nerve hyperexcitability disorders Paraneoplastic autonomic neuropathies and GI dysmotility Myasthenia Gravis – Pathophysiology, diagnosis and treatment Lambert-Eaton myasthenic syndrome Paraneoplastic myopathies Paraneoplastic autoantibodies Intracellular paraneoplastic autoantibodies Antibodies to neural cell surface and synaptic proteins in paraneoplastic neurologic syndromes Optimizing the diagnostic performance of neural antibody testing for paraneoplastic and autoimmune encephalitis in clinical practice Paraneoplastic neurological and autoantibody accompaniments of cancer Paraneoplastic Autoimmune Neurological Disorders associated with Thymoma Paraneoplastic Neurologic Manifestations of Neuroendocrine tumors Paraneoplastic Neurological Syndrome associated with Gynaecological and Breast malignancies Hematological malignancies and hematopoietic stem cell transplantation Paraneoplastic neurological syndrome and autoantibody accompaniments of germ cell tumors Neurological complications of cancer immunotherapy Neurological manifestations of autoimmunity with immune checkpoint inhibitors