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Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT), Volume 201 provides the latest information on what has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis, and many immune neuropathies. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to new insights on the pathological mechanisms underlying CNS autoimmunity, hence this volume summarizes that research.Reviews immunological mechanisms of HSCT and CNS autoimmunityIdentifies neurological diseases showing treatment efficacy with HSCTIncludes MS, myasthenia gravis, neuromyelitis optica, and moreCovers early and late side effects of HSCT
Dedication
Foreword
Preface
Contributors
Introduction to HSCT for neurologic diseases
Modification of T- and B-cell-associated immuno-pathologic mechanisms in multiple sclerosis by disease modifyi...
The hematopoietic niche and the autoreactive memory in autoimmune disorders
The preclinical data and immunologic rationale for hematopoietic stem cell transplantation in autoimmunity
Immune cell reconstitution following autologous hematopoietic stem cell transplantation in multiple sclerosis
Immune reconstitution in rheumatic disease patients after autologous hematopoietic stem cell transplantation
The role of chemotherapy in hematopoietic stem cell transplantation for autoimmune disorders: From lymphoablat...
The HSCT procedure (I): Mobilization, collection, manipulation, and cryopreservation of a HSC graft
The HSCT procedure (II): Conditioning, hematopoietic stem cell infusion, supportive care, and monitoring
Early and late complications of hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation for multiple sclerosis
Hematopoietic stem cell transplantation for neuromyelitis optica spectrum disorder. Can immune tolerance be r...
History of Neuromyelitis Optica Spectrum Disorder (NMOSD)
Hematopoietic stem cell transplantation (HSCT) for chronic inflammatory demyelinating polyradiculoneuropathy...
HSCT for stiff person syndrome and myasthenia gravis
Autologous hematopoietic stem cell transplantation for pediatric autoimmune neurologic disorders
HSCT for systemic autoimmune diseases with neurologic involvement
Hematopoietic stem cell therapy and ex vivo gene therapy for X-linked adrenoleukodystrophy
Economics of hematopoietic stem cell transplant in immune-mediated neurologic autoimmune diseases
The EBMT-ADWP and the CIBMTR
Ongoing randomized clinical trials on HSCT in multiple sclerosis
Index