Textbook in PDF format

This comprehensive resource skillfully consolidates crystal engineering, the design of organic solids, and supramolecular synthons (i.e., structural hydrogen bond units) to achieve desired pharmaceutical properties, including solubility, dissolution, bioavailability, permeability, particle size, tableting, hydration, and mechanical strength. Covering 30 years of crystal engineering developments and pharmaceutical applications, this book will be a single and complete resource for supramolecular and structural chemists, the crystal engineering community, pharmaceutical scientists, and industrial researchers.
Key Features:
Covers the fundamentals of crystal engineering and supramolecular synthons.
Details the challenges of low solubility and low permeability facing oral drug formulations.
Explains how heterosynthons provide a rational approach to address and implement solutions.
Provides case studies from academic and industrial labs to walk the reader through the actual steps.
Explores developments in the scale up and manufacture of crystal forms in pharmaceutical industry.
Introduction to Supramolecular Chemistry and Crystal Engineering
Crystal Engineering, Supramolecular Synthons, and Cocrystal Design
Pharmaceutical Solid-State Forms
Design and Methodology of Pharmaceutical Cocrystals
Applications of Pharmaceutical Cocrystals
Continuous Manufacturing of Cocrystals and Salts
Commercial Outlook of Pharmaceutical Cocrystals
Controlling Polymorphism
Supramolecular Heterosynthon in High Bioavailability Drugs
Other Applications of Cocrystals
AI ML ChatGPT in Chemistry
3D Electron Diffraction
Challenges, Conclusions, and Future Directions