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The book Nanoarchitectonics for Brain Drug Delivery (Advances in Bionanotechnology) discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug- delivery approaches. It highlights the current route for the intranasal advanced drug- delivery systems for brain diseases. It also discusses innovative categories of drug- delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid- based nanocarriers through multi- responsive DDSs and their implications in brain disorders.
The main features of Nanoarchitectonics for Brain Drug Delivery (Advances in Bionanotechnology) are:
Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches.
Focuses on theoretical aspects of advanced drug- delivery systems for brain diseases including challenges and progress in nose- to- brain delivery.
Provides an overview of technological approaches and their implications for neurodegenerative disorders, central nervous system (CNS), and brain drug delivery in brain cancer.
Discusses key advances in the development of polymer nanoparticles for drug delivery to the CNS.
Reviews the role of herbal medicines and naturally derived polymeric nanoparticle for the treatment of neurodegenerative disorders.
This book is aimed at graduate students and researchers in biomedical engineering, biotechnology, drug delivery, and neurology.
Contents
Preface...ix
List of Contributors...xi
About the Editors...xv
Acknowledgements...xvii
Chapter 1 Nanomedicine at the Forefront: Transforming Brain Drug Delivery with Innovative Strategies...1
Snigdha Singh, Anurag Kumar Singh, Anand Maurya, Vivek K. Chaturvedi, Jay Singh, and Santosh Kumar Singh
Chapter 2 Brain Diseases: An Introduction and the Need for Novel Drug- Delivery Approaches...16
Sukamto S. Mamada, Mirnawati Salampe, Rohit Sharma, Achmad Himawan, and Firzan Nainu
Chapter 3 Advanced Drug- Delivery Systems for Brain Diseases across the Blood– Brain Barrier...49
K. Trideva Sastri, Hitesh Kumar, Arshad J. Ansari, Anurag Kumar Singh, and Iliyas Khan
Chapter 4 Challenges and Progress in Nose- to- Brain Drug Delivery...71
Achmad Himawan, Sandra Aulia Mardikasari, Gábor Katona, Lalitkumar K. Vora, Anjali Kiran Pandya, Andi Dian Permana, Juhaina M. Abu Ershaid, Eeneko Larrañeta, and Vandana Patravale
Chapter 5 Mesoporous Silica Nanoparticles for Drug Delivery in Brain Disorders...106
Abhay Dev Tripathi, Aditi Bhatnagar, Soumya Katiyar, and Abha Mishra
Chapter 6 Polymeric Nanocarriers for Drug Delivery to the Central Nervous System...122
Aditya Kadam, Shradha Karande, Shreya Thakkar, Namdev More, and Dilip Sharma
Chapter 7 Lipid- Based Nanocarriers for Brain Delivery of Drugs in Neurodegenerative Disorders...148
Mukesh Kumar Yadav, Manish Singh, Pritee Chaudhary, and Shardendu Kumar Mishra
Chapter 8 Combination of Drug Delivery through Nanocarriers for Brain Diseases...172
Hagera Dilnashin, Shekhar Singh, Richa Singh, and Surya Pratap Singh
Chapter 9 Targeting Brain Cancer Using Advanced Nanoparticulate Drug- Delivery Systems...185
Vikash Kumar
Chapter 10 Herbal Medicines: A Boon for a Healthy Brain...210
Fajar Sofyantoro, Andri Frediansyah, Wahyu Aristyaning Putri, Winda Adipuri Ramadaningrum, Firzan Nainu, and Rohit Sharma
Chapter 11 Natural Polymeric Nanoparticles for Brain Targeting...249
Gaurav K. Pandit, Ritesh K. Tiwari, Ashish Kumar, Veer Singh, Gufran Ahmed, Shazia Kazmi, Shaliha Irfan, Vishal Mishra, Anurag Kumar Singh, Snigdha Singh, and Meenakshi Singh
Chapter 12 Herbal Drug- Loaded Nanoparticles for the Treatment of Neurodegenerative Diseases...266
Soumya Katiyar, Shikha Kumari, Abhay Dev Tripathi, Ritika Singh, Pradeep K. Srivastava, and Abha Mishra
Chapter 13 Neuropharmacological Potential of Ayurvedic Nanomedicines...297
Pankaj Kumar
Chapter 14 Insights into Progressive Perspectives of Solid Lipid Nanoparticles in Brain Targeting...321
Debarshi Kar Mahapatra, Ratiram G. Choudhary, Kanhaiya M. Dadure, Animeshchandra G. M. Haldar, and Rohit Sharma
Index...357
About the Authors
Anurag Kumar Singh is currently working as a Postdoctoral Research Assistant in Cancer Biology Research and Training at the Department of Biological Sciences, Alabama State University (USA). He has completed his doctoral degree from the Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India. He earned M. Pharm degree from the School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer, Rajasthan, India. His scholarly interests range from developing novel nano-particulate systems for brain-targeted drug delivery, including dendrimer, nanoporous silica/silicon materials, and polymeric-based nanoparticles for controlled drug delivery to diagnostics and therapy. His research interests include the development of nanoparticles/nanomedicines for biomedical and healthcare applications and building a bridge between engineering, pharmaceutical, and medical research. He has published several research papers, including reviews, journal editorials, and book chapters in various peer-reviewed National and International journals.
Vivek K. Chaturvedi is a Young-Scientist Fellow (Department of Health Research, Ministry of Health and Family Welfare) at Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. Before joining the laboratory as Young-Scientist Fellow, He worked as Postdoctoral research associate at Department of Gastroenterology, IMS-BHU, Varanasi. He earned his Ph.D. degree in Biotechnology from University of Allahabad (a central university), Prayagraj, India. He has received his B.Sc. degree in Zoology, Chemistry and M.Sc. degree in Biochemistry from Veer Bahadur Singh Purvanchal University, Jaunpur, India. Dr. Chaturvedi’s research interests include the synthesis and functionalization of nanomaterials as well as their fabrication for the development of various biosensors that may be useful for the early detection and treatment of Cancer and Gastrointestinal diseases. He has voluntarily served as reviewer and published a number of original articles in peer-reviewed high impact journals along with many international books, magazine articles and chapters.
Jay Singh is currently working as an Assistant Professor at the Department of Chemistry, Institute of Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, since 2017. He received his Ph.D. degree in Polymer Science from Motilal Nehru National Institute of Technology in 2010 and obtained his MSc and BSc from Allahabad University, Uttar Pradesh, India. He has held postdoctoral fellowships at the National Physical Laboratory, New Delhi, Chonbuk National University, South Korea, and Delhi Technological University, Delhi. Dr. Jay has been honored with prestigious fellowships such as CSIR (RA), DST-Young Scientist Fellowship, and DST-INSPIRE Faculty Award. His research focuses on the development of chemically and biologically synthesized nanomaterials and their nanobiocomposites, conducting polymers, and self-assembled monolayers. He is dedicated to creating clinically significant biosensors and sensors for the estimation of various bioanalytes based on enzymes, antibodies, DNA, and toxic chemicals and gases. With over 100 international research papers published and a total citation count exceeding 4000, Dr. Jay possesses an h-index of 36. He has successfully completed or is currently running various research projects funded by different agencies. Moreover, he has authored/edited more than 15 books and contributed over 40 book chapters for internationally renowned publishers. Dr. Jay has also handled special issues in esteemed journals. Currently, his active research involves the fabrication of sustainable metal oxide-based biosensors for clinical diagnosis, food packaging applications, drug delivery, and tissue engineering. His work has significantly contributed to the understanding of interfacial charge transfer processes and sensing capabilities of metal nanoparticles