Join an incredible journey through the history, chemistry and societal impacts of the world’s most extraordinary drugs.

EPISODES

S1 EP1

THE STORY OF THE SOUTH AFRICAN QUAALUDE

South Africa is the last place on earth Quaaludes can still be found. Hamilton travels there to study the drug and finds a dark history of medical experimentation.


S1 EP2

A POSITIVE PCP STORY

Hamilton travels across the USA meeting with addicts, dealers, and chemists to trace the history of PCP from its pharmaceutical origins to its escape onto the streets.

S1 EP3

SHEPHERDESS: THE STORY OF SALVIA DIVINORUM

From the heavenly cloud forests of Oaxaca to a viral video of Miley Cyrus, Hamilton investigates the inconspicuous yet extraordinary psychedelic plant Salvia divinorum.

S1 EP4

MAGIC MUSHROOMS IN MEXICO

From the Aztec empire to the underground laboratory, Hamilton explores magic mushrooms with the help of shamans, clandestine growers, and ethnomycologists.

S1 EP5

FISH N’ TRIPS

Hamilton embarks on an aquatic adventure to Reunion Island and Madagascar to investigate icthyoallyeinotoxism and a twisted history of hallucinogenic fish.


S1 EP6

THE LAZY LIZARD SCHOOL OF HEDONISM

We meet with famed LSD chemist Casey Hardison in the Nevada desert and embark on a road trip to visit an unsung hero of psychedelic history--Darrell Lemaire.

S2 EP1

THE PSYCHEDELIC TOAD

Hamilton embarks on a quest to answer the most important question in ethnoherpetological history and along the way, he finds the power of love.

S2 EP2

PEYOTE: THE DIVINE MESSENGER

From the greenhouses of Thai cactophiles to the Tamaulipan thornscrub, Hamilton traces the history of peyote with the help of a Native American peyotist.

S2 EP3

KRATOM: THE FORBIDDEN LEAF

Hamilton investigates the pharmacology and traditional uses of Kratom, a Thai tree with opioid-containing leaves.


S2 EP4

WIZARDS OF DMT

Hamilton travels across North America to study how and why DMT exists in the environment and the laboratory.


S2 EP5

KETAMINE: REALMS AND REALITIES

Hamilton heads to India to see industrial Ketamine synthesis, and speak with therapists and luminaries in an attempt to understand the role of dissociative anesthetics in society.

S2 EP6

A CLANDESTINE CHEMIST’S TALE

Hamilton meets an unsung hero of the psychedelic underground and hears a tragic tale of MDMA synthesis and chemiluminescence.

S2 EP7

A FUNGAL FAIRY TALE

Hamilton ascends the Carpathian Mountains, microscope in hand, to learn how Europeans use Amanita muscaria, and uncovers the chemistry behind a mushroom-inspired pharmaceutical.

S2 EP8

THE CACTUS APPRENTICE

Deep in the Andean highlands of Peru, Hamilton becomes the apprentice of a local shaman, learning how to use the night-blooming San Pedro cactus as a medicine.

S3 EP1

SYNTHETIC TOAD VENOM MACHINE

Haunted by past mistakes, Hamilton embarks on a journey to correct an error in his reporting and identifies the origin of an international toad venom smoking phenomenon.

S3 EP2

A POSITIVE METHAMPHETAMINE STORY

From X-ray crystallography to vesicular dopamine release, Hamilton travels the country visiting meth labs in order to understand the process behind a dying American folk art.

S3 EP3

XENON: THE PERFECT ANESTHETIC?

Hamilton traces the multi-billion-year history of nitrous oxide on Earth and follows the strangest noble gas to the Czech Republic.

S3 EP4

SYNTHETIC IBOGAINE — NATURAL TRAMADOL

Investigating a scientific mystery surrounding tramadol-addicted cattle in Central Africa, Hamilton follows a struggling local addict to a psychedelic ritual.

S3 EP5

BUFOTENINE: IN SEARCH OF HATAJ

Succumbing to viewer requests, Hamilton journeys to Argentina to understand Anadenanthera, one of the world's oldest psychedelics.

S3 EP6

ULTRA LSD

With the precise structure of LSD’s molecular target identified, Hamilton discusses a new era of psychedelic research and, along the way, meets pioneers of the field